منابع مشابه
Somatic hypermutation signature in B-cell low-grade lymphomas.
BACKGROUND Immunoglobulin gene somatic hypermutation is a biologically relevant and clinically useful prognostic factor in different types of low-grade B-cell lymphomas, including chronic lymphocytic leukemia, mantle cell lymphoma and splenic marginal zone lymphoma. DESIGN AND METHODS With the aim of identifying surrogate markers of somatic hypermutation, a combined investigation of IgV(H) mu...
متن کاملSomatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma.
The origin of low-grade mucosa-associated lymphoid tissue (MALT)-type B-cell lymphoma is still unclear. Using a novel two-step procedure, we have sequenced the Ig VH genes expressed by cells from four patients with gastric low-grade MALT-type lymphoma. The nucleotide sequences of the complementarity determining region 3 (CDR3) of the genomic DNA were first amplified using consensus oligonucleot...
متن کاملAlgorithm for immunophenotyping of low-grade B lymphomas.
In September 1994, Harris et al' published their Proposal for a Revised European-American Classification of Lymphoid Neoplasms. We have found their report extremely useful for practical work and consider i t a great step forward in the understanding of the biologic behavior of lymphomas for the following reasons. (1) They postulated the presumed normal counterpm of the lymphoma cell and also de...
متن کاملVH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching.
Primary cutaneous B-cell lymphomas are B-cell non-Hodgkin's lymphomas that arise in the skin. The major subtypes discerned are follicle center cell lymphomas, immunocytomas (marginal zone B-cell lymphomas), and large B-cell lymphomas of the leg. In this study, we analyzed the variable heavy chain (VH) genes of 7 of these lymphomas, ie, 4 follicle center cell lymphomas (diffuse large-cell lympho...
متن کاملPrimary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation.
We have addressed whether aberrant ongoing hypermutation can be detected in the proto-oncogenes PIM1, c-MYC, RhoH/TTF, PAX5, and the tumor-suppressor gene CD95 in primary central nervous system lymphomas (PCNSLs) derived from immunocompetent HIV-negative patients. Nine of 10 PCNSLs analyzed harbored somatic mutations in the PIM1, c-MYC, RhoH/TTF, and PAX5 genes, but not in the CD95 gene, with 8...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2008
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.12999